[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"kakomon-q-2025-ippan-42":3},{"slug":4,"exam_year":5,"exam_round":6,"section":7,"section_code":8,"number":9,"body":10,"choices":11,"correct_indices":28,"explanation":29,"has_explanation":15,"tags":30},"2025-ippan-42",2025,3,"一般","ippan",42,"犬で初回通過効果を最も受ける投与方法はどれか。",[12,16,20,22,25],{"index":13,"body":14,"is_correct":15},1,"経口投与",true,{"index":17,"body":18,"is_correct":19},2,"経直腸投与",false,{"index":6,"body":21,"is_correct":19},"筋肉内投与",{"index":23,"body":24,"is_correct":19},4,"皮下投与",{"index":26,"body":27,"is_correct":19},5,"静脈内投与",[13],"正答は1（経口投与）。初回通過効果（肝初回通過効果）は、消化管から吸収された薬物が門脈を通って肝臓を通過する際に代謝を受けることで、経口投与が最も影響を受ける。2経直腸投与は一部が門脈を回避、3筋肉内・4皮下・5静脈内投与は消化管吸収を経ないため初回通過効果を受けない。",null]